A REVIEW OF 095489 41827

Activated CHK2 and CHK1 phosphorylate numerous downstream effectors to amplify and relay the signals to induce DNA hurt responses (DDRs) these as cell cycle arrest, senescence, or apoptosis (25,59,60). ATR-CHK1 is at the center on the DDR, specifically in the RSR (23,sixty four). ATR orchestrates numerous branches of RSR by signaling to arrest cell

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